Pharm Ingredients
Natto Extract Nattokinase Powder
Natto Extract Nattokinase Powder Manufacturers
As a company specializing in the production of nattokinase extracts, Kintainutri® derives its premium extract from non-GMO fermented soybeans. Through standardization, we ensure a high content of highly active natto extract nattokinase powder, with enzymatic activity ranging from 5,000 to 50,000 FU/g. Utilizing advanced multi-stage separation and low-temperature drying processes, We provide a highly stable raw material that is completely free of Vitamin K2 and devoid of the pungent odors typically associated with fermentation, making it a reliable bulk ingredient for global manufacturers developing innovative health supplements and high-end pharmaceutical products.
Nattokinase powder refers to a complex of active ingredients isolated from natto (soybeans fermented with Bacillus subtilis), with nattokinase serving as the core and most representative functional component. During fermentation, soybean proteins are enzymatically broken down into small-molecule amino acids, bioactive peptides, and oligosaccharides, while various digestive and thrombolytic enzymes are produced.
Collectively, these constitute the natto extract nattokinase powder. It offers multiple physiological benefits, including thrombolysis (dissolving blood clots), blood pressure management, and lipid profile improvement, and is widely used in functional foods, health supplements, and pharmaceutical formulations. In simple terms, nattokinase extract is a concentrated and purified product containing the beneficial components of natto—most notably nattokinase itself.
| Item | Specification | Method | |
|---|---|---|---|
| Product Name | Natto Extract Nattokinase Powder | ||
| Physical and Chemical Property | |||
| Appearance | Yellow-white fine powder | Visual | |
| Particle Size (80 mesh) | ≥95% | Screening | |
| Residue on Ignition | ≤1g/100g | 3g/550℃/4hrs | |
| Loss on Drying | ≤5g/100g | 3g/105℃/2hrs | |
| Identification (TLC) | Conforms with standard | TLC | |
| Content (Nattokinase) | ≥2000 FU/g | UV | |
| Residue Analysis (Heavy Metals) | |||
| Heavy Metals | ≤10mg/kg | — | |
| Lead (Pb) | ≤1.00mg/kg | ICP-MS | |
| Arsenic (As) | ≤1.00mg/kg | ICP-MS | |
| Cadmium (Cd) | ≤1.00mg/kg | ICP-MS | |
| Mercury (Hg) | ≤0.50mg/kg | ICP-MS | |
| Microbiological Tests | |||
| Total Plate Count | ≤1000 cfu/g | AOAC 990.12 | |
| Total Yeast & Mold | ≤100 cfu/g | AOAC 997.02 | |
| E. Coli | Negative/10g | AOAC 991.14 | |
| Salmonella | Negative/10g | AOAC 998.09 | |
| S. Aureus | Negative/10g | AOAC 2003.07 | |
| Product Status | |||
| Conclusion | Sample Qualified | ||
| Shelf Life | 24 months under the conditions below and in its original packaging | ||
| Retest Date | Every 24 months under the conditions below and in its original packaging | ||
| Storage Condition | Store in a cool, dry place away from moisture & light | ||
How To Make Natto Extract Nattokinase Powder?
Natto Extract Nattokinase Powder Benefits
Nattokinase for blood clots
The natto extract nattokinase powder raw material supplied by Kintainutri® Extract Company demonstrates thrombolytic and antithrombotic activity superior to plasmin and comparable to aspirin in animal studies. Clinical trials confirm that a single oral dose of 2,000 FU effectively degrades fibrin and inhibits coagulation, with effects lasting over eight hours—far exceeding the 4–20 minute half-life of t-PA. Its multi-target mechanism involves directly degrading fibrin, increasing t-PA release, inactivating PAI-1, inhibiting platelet aggregation, reducing levels of fibrinogen and factors VII/VIII, and hydrolyzing thrombin.
Daily doses of 2,000–3,600 FU can significantly improve the prothrombotic state in patients with hypercholesterolemia. We provide high-activity, high-purity nattokinase raw materials and support OEM/ODM formulation development, helping brands create cardiovascular health products with distinct mechanistic advantages.
Nattokinase blood pressure
Natto extract (nattokinase) has an adjunctive blood pressure-lowering effect. Clinical studies indicate that a daily oral dose of 2,000 FU for eight weeks significantly reduces both systolic and diastolic blood pressure in patients with prehypertension, stage 1 hypertension, and progressive hypertension, with particularly pronounced effects observed in male patients. The mechanism underlying this antihypertensive effect remains a subject of debate: some studies suggest that nattokinase inhibits angiotensin-converting enzyme (ACE), thereby blocking the production of angiotensin II; others find that it does not affect ACE levels but instead reduces renin activity; and still other theories propose that intact nattokinase exerts its effect by cleaving fibrinogen, while its fragments act by preventing the rise of angiotensin II. Nattokinase represents a promising adjunctive approach to hypertension management.
Nattokinase and cholesterol
Natto extract nattokinase powder demonstrates significant efficacy in ameliorating atherosclerosis. Research indicates that a sufficient daily dosage of 10,800 FU over 12 months effectively halts the progression of atherosclerosis and improves hyperlipidemia without adverse effects; a 26-week treatment regimen significantly reduces carotid intima-media thickness and plaque area, outperforming simvastatin. Potential mechanisms include the upregulation of paraoxonase-1 to inhibit LDL oxidation, alongside synergistic fibrinolytic, anti-inflammatory, and anticoagulant effects. It offers a comprehensive cardiovascular solution for premium nutritional and pharmaceutical formulations.
Nattokinase for inflammation
Nattokinase powder exhibits significant anti-inflammatory activity. Research indicates that nattokinase reduces the release of pro-inflammatory mediators and the production of reactive oxygen species by inhibiting LPS-induced TLR4 pathway activation and NADPH oxidase 2 (NOX2) activity. In a chronic colitis model, long-term nattokinase supplementation alleviates colonic injury and inhibits apoptosis, a mechanism associated with the downregulation of indoleamine 2,3-dioxygenase 1 (IDO-1) expression.
Furthermore, nattokinase mitigates neuroinflammation by activating the Nrf2/HO-1 pathway, thereby shifting pro-inflammatory microglia toward an anti-inflammatory phenotype. These anti-inflammatory effects may represent a key mechanism underlying the beneficial impact of nattokinase on age-related diseases, such as atherosclerosis, diabetes, and Alzheimer's disease.
What Is Natto Extract Nattokinase Powder Used For？
Natto health supplements are functional products made from natto or its active ingredients; common varieties include natto softgels, enteric coated nattokinase and natto extract capsules. Natto softgels typically contain freeze-dried natto powder, fructooligosaccharides, and flaxseed oil. In contrast, natto-red yeast rice capsules are formulated from natto and Monascus (red yeast rice) and are rich in active ingredients such as lovastatin, red yeast pigments, nattokinase, Bacillus subtilis (natto), and isoflavones; offering dual biological activity, they provide significant lipid-lowering and health-promoting benefits. While nattokinase supplement offer supportive health benefits, they cannot replace medical treatment for diseases.
Natto Extract Nattokinase Powder Side Effects, Risks, Safety
Nattokinase is generally recognized as safe (GRAS) for long-term dietary use; however, its potent thrombolytic and blood-thinning properties necessitate careful management of potential risks. Its primary side effects and risks center on an increased tendency to bleed; consequently, it is strictly contraindicated for individuals with coagulation disorders (such as hemophilia), those scheduled for surgery within two weeks, and patients currently taking clinical anticoagulants like warfarin or aspirin.
For individuals with normal liver function or mild hyperlipidemia and fatty liver, nattokinase extract is safe and beneficial, helping to protect hepatocytes and optimize hepatic lipid metabolism; however, for patients with severe liver disease accompanied by coagulation dysfunction, it may pose an indirect bleeding risk and should be used only under medical supervision.
Natto Extract Nattokinase Powder Dosage
| Target Application | Recommended Dosage | Product Positioning |
|---|---|---|
| Atherosclerosis / Hyperlipidemia (therapeutic) | >10,000 FU/day | High-dose clinical nutrition |
| Cardiovascular maintenance / Antithrombotic | 2,000 – 6,000 FU/day | Daily dietary supplement |
| Adjuvant antihypertensive | 2,000 FU/day | Blood pressure support formula |
| Post-stroke recovery | 1,200 – 2,000 FU/day | Rehabilitation functional food |
| Combination products | 2,000 – 6,000 FU/day | Co-formulated with red yeast rice, CoQ10, vitamin K₂ |
Where Can i Buy Natto Extract Nattokinase Powder?
Kintainutri® supplies high-purity nattokinase powder with high enzymatic activity, suitable for OEM/ODM production of health products, functional foods, and dietary supplements. Our natto extract nattokinase powder specifications range from 5,000 FU/g to 50,000 FU/g; we support customized formulations (such as blends with red yeast rice, Coenzyme Q10, or Vitamin K2) and offer various dosage forms, including freeze-dried powder, hard capsules, and softgels.
Our products strictly comply with international certifications such as ISO, GMP, Kosher, and Halal, and are consistently exported to markets in Europe, the Americas, and Southeast Asia. By choosing Kintainutri®, you gain access to a stable supply chain, comprehensive technical support, and flexible MOQs, helping your brand create highly competitive cardiovascular health products. Free samples are available—please contact us!
*Kintainutri® Promise All Products: Non-Irradiated / Non-ETO/ Treat by Heat Only / Non-GMO
FAQ
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Does nattokinase powder increase estrogen?
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